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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR2A All Species: 36.06
Human Site: S487 Identified Species: 79.33
UniProt: P24928 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P24928 NP_000928.1 1970 217176 S487 S T F R L N L S V T T P Y N A
Chimpanzee Pan troglodytes XP_511300 1913 211215 S487 S T F R L N L S V T T P Y N A
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_858599 1896 209574 S489 S T F R L N L S V T T P Y N A
Cat Felis silvestris
Mouse Mus musculus P08775 1970 217158 S487 S T F R L N L S V T T P Y N A
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZL98 1390 155685 Y97 L P C F H V G Y F K A V I G I
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_682682 1972 217631 S484 S T F R L N L S V T T P Y N A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P04052 1887 209150 S479 S T F R M N L S C T S P Y N A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P16356 1852 203961 S477 S T F R M N L S V T S P Y N A
Sea Urchin Strong. purpuratus XP_001176260 1921 212544 S487 S T F R L N L S V T T P Y N A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P18616 1840 204671 S488 S T F R L N L S V T S P Y N A
Baker's Yeast Sacchar. cerevisiae P04050 1733 191593 K431 I Q L Q Y G W K V E R H I M D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.7 N.A. 95.9 N.A. 99.9 N.A. N.A. N.A. 26.2 N.A. 94.9 N.A. 71.1 N.A. 67.4 77.6
Protein Similarity: 100 96.8 N.A. 96 N.A. 99.9 N.A. N.A. N.A. 40.8 N.A. 97.8 N.A. 84.1 N.A. 81 87.2
P-Site Identity: 100 100 N.A. 100 N.A. 100 N.A. N.A. N.A. 0 N.A. 100 N.A. 80 N.A. 86.6 100
P-Site Similarity: 100 100 N.A. 100 N.A. 100 N.A. N.A. N.A. 0 N.A. 100 N.A. 93.3 N.A. 100 100
Percent
Protein Identity: N.A. N.A. N.A. 57.4 50.1 N.A.
Protein Similarity: N.A. N.A. N.A. 71.9 64.8 N.A.
P-Site Identity: N.A. N.A. N.A. 93.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 100 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 82 % A
% Cys: 0 0 10 0 0 0 0 0 10 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % D
% Glu: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % E
% Phe: 0 0 82 10 0 0 0 0 10 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 10 10 0 0 0 0 0 0 10 0 % G
% His: 0 0 0 0 10 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 10 0 0 0 0 0 0 0 0 0 0 0 19 0 10 % I
% Lys: 0 0 0 0 0 0 0 10 0 10 0 0 0 0 0 % K
% Leu: 10 0 10 0 64 0 82 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 19 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 0 0 0 0 82 0 0 0 0 0 0 0 82 0 % N
% Pro: 0 10 0 0 0 0 0 0 0 0 0 82 0 0 0 % P
% Gln: 0 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 82 0 0 0 0 0 0 10 0 0 0 0 % R
% Ser: 82 0 0 0 0 0 0 82 0 0 28 0 0 0 0 % S
% Thr: 0 82 0 0 0 0 0 0 0 82 55 0 0 0 0 % T
% Val: 0 0 0 0 0 10 0 0 82 0 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 10 0 0 0 0 82 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _